No Evidence of a Drug-Drug Interaction Between Letermovir (MK-8228) and Mycophenolate Mofetil

Mycophenolate mofetil--a new atheropreventive drug?

Atherosclerosis is a form of chronic inflammation in which endothelial cell dysfunction, fibroproliferative process, oxidative stress and inflammatory cell activation are linked to plaque development and destabilization. T-lymphocytes also play a key role in pathogenesis of atherosclerosis. As a consequence, the suggested concept that modulation of an immunological response could be an appropri...

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil.

The immunosuppressive drug mycophenolate mofetil (MMF) is used to prevent organ rejection after transplantation and has shown some efficacy to prevent the fibrotic complications that occur during autoimmune diseases such as systemic sclerosis or during graft-versus-host disease (GVHD). We tested the hypothesis that MMF may exert direct effects on fibroblast extracellular matrix remodeling. Incu...

Evidence for efficacy of a drug widely used without authorisation in multiple sclerosis: mycophenolate mofetil.

Mycophenolate mofetil (MMF) is an oral DNA base synthesis inhibitor that has profound immunosuppressive effects on activated T cells, B cells and macrophages. MMF selectively inhibits inosine 50-monophosphate dehydrogenase type II, responsible for de novo synthesis of the purine nucleotide guanine. The drug has been used for anti-rejection therapy in organ transplantation and also for immunothe...

In vitro Evidence for a Direct Anti-Fibrotic Role of the Immunosupressive Drug Mycophenolate Mofetil